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Trololololpotato Trololololpotato 4 May 2020
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In the intrinsic pathway, factor XII, high molecular weight kininogen, prekallikrein, and activated factor XI (factor XIa) interact to produce factor IXa from factor IX. Factor IXa then combines with factor VIIIa and procoagulant phospholipid (present on the surface of activated platelets, endothelial cells, and tissue cells) to form a complex that activates factor X.


In the extrinsic pathway, factor VIIa and tissue factor (TF) directly activate factor X (and, perhaps, also factor IX—see figure Pathways in blood coagulation and table Components of Blood Coagulation Reactions).


Many (or most) coagulation proteins are produced in vascular endothelial cells, including the endothelial cells lining liver sinusoids. Some coagulation proteins may a…



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